JOSEPH MAILEN KOOTSEY


BIRTHPLACE: Houston, Texas, U.S.A.

CITIZENSHIP: USA

MARITAL STATUS: Married to Lynne Diane (Wiles) Kootsey

CHILDREN: Brenden Lamont Kootsey, Sean Alexander Kootsey


COMPETENCIES:


EDUCATION:


EMPLOYMENT EXPERIENCE:


HONORS AND AWARDS:


INVITED LECTURES:


COURSES TAUGHT: (U = undergraduate, G = graduate/medical)}


CONSULTANT FOR:


 PROFESSIONAL SOCIETY MEMBERSHIPS:


SOCIETY OFFICES:


RESEARCH INTERESTS:


EXAMPLES OF BIOMEDICAL MODELS STUDIED:


REVIEWER FOR:


EDITORIAL EXPERIENCE:


BOARD OF DIRECTORS MEMBERSHIPS


CHAPTERS IN BOOKS:

1. Kootsey, J.M., Johnson, E.A. Origin of the electrocardiogram. Relationship between transmembrane potential and electrocardiogram. In: The Theoretical Basis of Electrocardiology. Editors: Nelson, C.V., and D.B. Geselowitz. Clarendon Press, Oxford, 1976, pp 21-43.

2. Kootsey, J.M. Reproductive technology. In: Seminar on Genetic Engineering. Dept. of Health, Gen. Conf. of Seventh-day Adventists, Washington, D.C., 1979, pp 93-113.

3. Kootsey, J.M. Modelling active and passive sodium and potassium ion transport. In: QUANTITATIVE APPROACHES TO METABOLISM: The Role of Tracers and Models in Clinical Medicine. Editor: D.G. Cramp, John Wiley & Sons, Limited, Chichester, England, 1982, pp 247-281.

4. Kootsey, J.M., Wu, J. Models of electrophysiological activation. In: Imaging, Measurement and Analysis of the Heart. Editors: S. Sideman and R. Beyar. Hemisphere Publishing Corporation, New York, 1991, pp 373-381.

5. Kootsey, J.M. Electrical propagation in distributed cardiac tissue. In: Theory of Heart: Biomechanics, Biophysics, and Nonlinear Dynamics of Cardiac Function. Editors: L. Glass, P. Hunter, and A. McCulloch, Springer-Verlag, New York, 1991, pp 391-403.


ARTICLES IN PROFESSIONAL JOURNALS:

1. Kootsey, J.M. Particle discrimination system for nuclear reaction studies. Nuc. Inst. and Meth. 35:141-147 (1965).

2. Kootsey, J.M. Interaction of 14.1 MeV neutrons with tritons. Nuclear Physics A113:65-74 (1968).

3. Kootsey, J.M. FET and IC keep oscillator linear. Electronics 40:17:84 (1968).

4. Kootsey, J.M., Collier, C.R., Hackney, J.D. Acid base computer for teaching and clinical applications. Med. Res. Engr. 10:18-20 (1971).

5. Spach, M.S., Lieberman, M., Scott, J.G., Barr, R.C., Johnson, E.A., Kootsey, J.M. Excitation sequences in the atrial septum and the A-Vnode in isolated hearts of the dog and rabbit. Circ.Res. 29:156-172 (1971).

6. Spach, M.S., Barr, R.C., Serwer, G.S., Kootsey, J.M., Johnson, E.A. Collision of excitation waves in the dog Purkinje system. Circ. Res. 29:499-511 (1971).

7. Spach, M.S., Barr, R.C., Serwer, G.S., Kootsey, J.M., Johnson, E.A. Extracellular potentials related to intracellular action potentials in the dog Purkinje system. Circ. Res. 30:505-519 (1972).

8. Kootsey, J.M., Johnson, E.A. Voltage clamp of cardiac muscle: A theoretical analysis of early currents in the single sucrose gap. Biophys. J. 12:1496-1508 (1972).

9. Lieberman, M., Kootsey, J.M., Johnson, E.A., Sawanobori, T. Slow conduction in cardiac muscle: A biophysical model. Biophys. J. 13:37-55 (1973).

10. Kootsey, J.M., Johnson, E.A. Buffer amplifier with femtofarad input capacity using operational amplifiers. IEEE Trans. Biomed. Eng. 20:389-391 (1973).

11. Spach, M.S., Barr, R.C., Johnson, E.A., Kootsey, J.M. Cardiac extracellular potentials. Analysis of complex waveforms about the Purkinje networks in dogs. Circ. Res.33:465-473 (1973).

12. Kootsey, J.M. Voltage clamp simulation. Fed.Proc. 34:1343-1349 (1975).

13. Lieberman, M., Sawanobori, T., Kootsey, J.M., Johnson, E.A. A synthetic strand of cardiac muscle. Its passive electrical properties. J. Gen. Physiol. 65:527-550 (1975).

14. Kootsey, J.M., Johnson, E.A., Lieberman, M. The cylindrical cell with a time-variant membrane resistance: Measuring passive parameters. Biophys. J. 17:145-154 (1977).

15. Kootsey, J.M. The steady-state finite cable: Numerical method for non-linear membrane. J. Theor. Biol. 64:413-420 (1977).

16. Kim, Y.S., Kootsey, J.M., Padilla, G.M. An inexpensive solvent gradient system for liquid chromatography. Anal. Biochem. 78:283-286 (1977).

17. Chapman, J.B., Kootsey, J.M., Johnson, E.A. A kinetic model for determining the consequences of electrogenic active transport in cardiac muscle. J. Theor. Biol. 80:405-424 (1979).

18. Johnson, E.A., Chapman, J.B., Kootsey, J.M. Some electrophysiological consequences of electrogenic Na,K transport in cardiac muscle: A theoretical study. J. Theor. Biol. 87:737-756 (1980).

19. Kootsey, J.M.,Johnson, E.A. The origin of the T-wave. CRC Crit. Revs. in Bioeng. 4:233-270 (1980).

20. Kootsey, J.M., Johnson, E.A., Chapman, J.B. Electrochemical inhomogeneity in ungulate Purkinje fibers: model of electrogenic transport and electrodiffusion in clefts. Adv. Physiol. Sci. Cardiovascular Physiology. Heart, Peripheral Circulation, and Methodology. A.G.B. Kovach, E. Monos, G. Rubanyi, eds. 8:83-92 (1980).

21. Spach, M.S., Miller, W.T., III Geselowitz, D.B., Barr, R.C., Kootsey, J.M., Johnson, E.A. The discontinuous nature of propagation in normal canine cardiac muscle. Evidence for recurrent discontinuities of intracellular resistance that affect the membrane currents. Circ. Res. 48:39-54 (1981).

22. Spach, M.S., Miller, W.T., III Dolber, P.C., Kootsey, J.M., Sommer, J.R., Mosher, C.E. Jr. The functional role of structural complexities in the propagation of depolarization in the atrium of the dog. Cardiac conduction disturbances due to discontinuities of effective axial resistivity. Circ. Res. 50:175-191 (1982).

23. Spach, Madison S., Kootsey, J. Mailen, Sloan, Joseph D. Active modulation of electrical coupling between cardiac cells: A mechanism for transient and steady-state variations in conduction velocity. Circ. Res. 51:347-362 (1982).

24. Spach, Madison S., Kootsey, J. Mailen. The nature of electrical propagation in cardiac muscle. Am. J. Physiol. 244:H3-H22 (1983).

25. Chapman, J.B., Johnson, E.A., Kootsey, J.M. Electrical and biochemical properties of an enzyme model of the sodium pump. J. Memb. Biol. 74:139-153 (1983).

26. Kootsey, J.M., Holt, D.C. A general-purpose interactive control program for simulations on microcomputers. Modeling and Simulation on Microcomputers (SCS), pp 37-40 (1984).

27. Spach, M.S., and Kootsey, J.M. Relating the sodium current and conductance to the shape of transmembrane and extracellular potentials by simulation: Effects of propagation boundaries. IEEE Trans. Biomed. Engr. BME-32:743-755 (1985).

28. Kootsey, J.M. Guest editorial: Special issue on computer simulation in biomedicine. IEEE Trans. Biomed. Engr. BME-32:729-730 (1985).

29. Johnson, E.A., Kootsey, J.M. A minimum mechanism for Na-Ca exchange: Net and unidirectional Ca++ fluxes as functions of ionic composition and membrane potential. J. Memb. Biol. 86:167-187 (1985).

30. Kootsey, J.M. Marketing simulation in the biomedical community. Proc. Simulation Prof. Conf. (Society for Computer Simulation, San Diego, CA) (1985).

31. Kootsey, J.M. The National Biomedical Simulation Resource: Microcomputers to megacomputers. Proc. Summer Comp. Sim. Conf. pp 482-484. (Society for Computer Simulation, San Diego, CA)(1985).

32. Kootsey, J.M. Computer simulation: A thinking tool for education and research in biomedicine. Proc. Symp. Computer Applications in the Health Sciences (Tuskegee Univ.), p 98-106, 1985.

33. Kootsey, J.M. Computer simulation for biomedical research. Lab Animal 14:35-38 (1985).

34. Kootsey, J.M., Johnson, E.A. Reconstruction of transport currents during repolarization: biochemical basis. Jap. Heart J. 27:S1:109-126 (1986).

35. Kootsey, J.M. Future directions in computer simulation. Bull. Math. Biol. 48:405-415 (1986).

36. Kootsey, J.M., Kohn, M.C., Feezor, M.D., Mitchell, G.R., and Fletcher, P.R. SCoP: An interactive simulation control program for micro- and minicomputers. Bull. Math. Biol. 48:427-441 (1986).

37. King, R., Budd, R., Bassingthwaighte, J., and Kootsey, J.M. A simulation system for biomedical investigators. Proc. Summer Comp. Sim. Conference, pp 386-389 (Society for Computer Simulation, La Jolla, CA)(1986).

38. Kootsey, J.M. Complexity and significance in computer simulations of physiological systems. Fed. Proc. 46:2490-2493 (1987).

39. Spach, M.S., Dolber, P.C., Heidlage, J.F., Kootsey, J.M., and Johnson, E.A. Propagating depolarization in anisotropic human and canine cardiac muscle: apparent directional differences in membrane capacitance. Circ. Res. 60:206-219 (1987).

40. Kootsey, J.M. Membrane mechanisms of ion transport. Proc. IEEE/Ninth Annual Conf. Eng. Med. Biol. pp 885,6 (1987).

41. Kootsey, J.M. State diagrams: A tool for physiological models. Proc. Second Symp. Biomed. Infor. Manag. Systems, pp 241-249 (1987).

42. Kootsey, J.M., Wu, J. Anisotropic 2-D model of electrical propagation in cardiac muscle. Proc. IEEE/Tenth Annual Conf. Eng. Med. Biol. 10:956-957 (1988).

45.5. Stead, W.W., Bird, W.P., Carter, R., Elchlepp, J., Hammond, W.E., Kootsey, J.M., and Smith, P.K. IAIMS: The role of strategic planning. Symp. Comp. Appl. Med. Care. 345-349 (1989).

43. Kootsey, J.M. SCoP 4: A general-purpose interactive simulation package for personal computers. Modeling on Micros and Workstations, ed. by T.A. Rathburn, (Soc. Comp. Sim., San Diego, CA, 1991), pp 21-25.

44. Kootsey, J.M., Pusateri, T.J. SimSys: A distributed simulation environment for workstations. Simulation Work and Progress, ed. by Y. Sahinkaya and R. Nilsen, (Soc. Comp. Sim., San Diego, CA, 1991), pp 81-85.

45. Vaughan, P., Kootsey, J.M., Feezor, M.D. Kinetic analysis of chloride conductance in frog skeletal muscle at pH 5. Pflugers Arch. 419:522-528 (1991).

46. Lemieux, D.R., Kootsey, J.M. Simulation of the voltage dependence of the Na,K pump applied to cardiac cells. J. Theor. Biol. 150:73-91 (1991).

47. Johnson, E.A., Lemieux, D.R., and Kootsey, J.M. Sodium-calcium exchange: Derivation of a state diagram and rate constants from experimental data. J. Theor. Biol. 156:443-483 (1992).

48. Kootsey, J.M. Complex simulation models in the SCoP language. Simulation in Health Sciences and Services, ed. by J.G. Anderson and M. Katzper, (Soc. Comp. Sim., San Diego, CA 1993) pp 57-61.

49. Kohn, M.C., Hines, M.L., Kootsey, J.M., and Feezor, M.D. A block organized model builder. Mathl. Comput. Modeling 19:6-8:75-97 (1994).

50. Kootsey, J.M. Simulation is real. Proc. 1996 IEEE International Conf. on Multimedia in Engineering Education, pp 29-36 (1996).

51. Kelly, H.F., Chapman, J.B., and Kootsey, J.M. New simulation resources for electronic authors. Proc. 1996 IEEE International Conf. on Multimedia in Engineering Education, pp 41-48 (1996).

52. Wu., J., Johnson, E.A., Kootsey, J.M. A quasi-one-dimensional theory for anisotropic propagation of excitation in cardiac muscle. Biophys. J. 71:2427-2439 (1996).

53. Kootsey, J.M. Software for the third branch of science: Experimental theory. Found. Comp. Decis. Sci. 22:95-106 (1997).

54. Kootsey, J.M., McAuley, G., Liu, H. Presenting systems concepts in physiology and pharmacology with simulation applets in Java. Proceedings 23rd Annual Conference IEEE/EMBS Oct. 25-28, 2001, Istanbul, Turkey (paper #661, 4 pages).

55. Kootsey, J.M., McAuley, G., Liu, H. Using XML to Specify and Manage Biomedical Simulation Model descriptions, Health Sciences Simulation 2002, J.G. Anderson and M. Katzper, eds., Society for Computer Simulation, San Diego, CA, pp 103-108 (2002).

56. Kootsey, J.M., McAuley, G. NLX: Building Web pages with interactive calculations in minutes. Proceedings 25th Annual Conference IEEE/EMBS (Cancun, Mexico, 2003) pp 3505-3508.

57. Kootsey, J.M., McAuley, G., Siriphongs, D. NLX: Rapid Construction of Interactive Simulations for the Web. Health Sciences Simulation 2004, J.G. Anderson and M. Katzper, eds., Society for Computer Simulation, San Diego, CA, pp 124-127 (2004).

58. Kootsey, J.M., Siriphongs, D., McAuley, G. Building Interactive Simulations in a Web Page Design Program. Proceedings 26th Annual Conference IEEE/EMBS (San Francisco, California, USA, 2004) pp 5166-5168.

59. Kootsey, J.M., McAuley, G., Bernal, J. Building Interactive Simulations in Web Pages without Programming. Proceedings 27th Annual Conference IEEE/EMBS (Shanghai, China)(2005).

60. Kootsey, J.M. Interactive Simulation in Web Pages: A System for Rapid Development. Proceedings Asia Modeling Symposium AMS2007 (IEEE, Phuket, Thailand, 2007) pp 556-561.

61. Kootsey, J.M., McAuley, G. Rapid Construction of Simulation-Driven Animations In Web Pages Using NLX and Flash. Proceedings of the 17th Annual International Conference on Health Sciences Simulation (Soc. Computer Simulation and ACM, Ottawa, Canada, 2008) pp 609-613.

62. Kootsey, J.M., McAuley, G. NLX Plus Flash Equals Quick Simulation-Driven Animations. Second Asia International Conference on Modelling and Simulation (IEEE Computer Society, Kuala Lumpur, Malaysia, 2008) pp 375-378.

63. Teichgräber, V., Karanikas, V.,  Trumpheller, C., Kootsey, M., Gaffney, E.A., Brown, L.V., Phipps, A., Charoin, J.E., Acuna, G., Pisa, P., Wagg, J. Therapeutic cancer vaccines: Optimizing the delivery of short peptide vaccines to achieve successful clinical outcome. In Journal review, 2017.


ABSTRACTS AND COMMUNICATIONS:

1. Kootsey, J.M., Collier, C.R., Hackney, J.D. Acid base balance computer for teaching and clinical applications. Proc. Ann. Conf. Eng. Med. Biol. 10:36.5 (1968).

2. Grube, G., Goley, D., Kootsey, J.M., Paulsen, K.A., Bowyer, A.F. Atrioventricular node transfer function in man by atrial pacing. Proc. Ann. Conf. Eng. Med. Biol. 10:22A2 (1968).

3. Kootsey, J.M., Johnson, E.A. Extracellular potentials and the myocardial current generator. Suppl. 3 to Circ. 42:175 (1970).

4. Kootsey, J.M., Johnson, E.A. Extracellular potentials and the myocardial current generator. Biophys. J. 11:244A (1971).

5. Kootsey, J.M., Johnson, E.A. Voltage clamp of cardiac muscle. A theoretical analysis. Proc. Intern. Union of Physiol. Sci. 9:316 (1971).

6. Lieberman, M., Kootsey, J.M., Johnson, E.A., Roggeveen, A.E. Impulse propagation in geometrically oriented cardiac muscle cultured heart cells. Fed. Proc. 30:553A (1971).

7. Spach, M.S., Barr, R.C., Serwer, G.S., Johnson, E.A., Kootsey, J.M. Collision of excitation waves in the ventricular conduction system. Circ. 43 & 44:II-72 (1971).

8. Spach, M.S., Barr, R.C., Serwer, G.S., Johnson, E.A., Kootsey, J.M. Extracellular identification of collisions of excitation waves in the dog Purkinje system. Satellite Symp. XXVth Int. Congr. Physiol. Sci, The Electric Field of the Heart, Brussels, p 558 (1971).

9. Spach, M.S., Barr, R.C., Kootsey, J.M., Johnson, E.A. Genesis of extracellular potentials at varying distances from Purkinje fibers. Circ. 46:II-36 (1972).

10. Kootsey, J.M., Johnson, E.A. The repolarization phase of the cardiac action potential: An essentially time-independent system of conductance changes. Biophys. J. 13:130a (1973).

11. Anderson, P.A.W., Manring, A., Kootsey, J.M. The temperature-jump method for cardiac muscle: Separating the mechanism of membrane potential control of contraction ,from control at the contractile element level. Fed. Proc. 33:1259 (1974).

12. Kootsey, J.M., Vereecke, J., Shigeto, N., Lieberman, M., Johnson, E.A. Deciphering nonlinear membranes: Distortion from cable length. Biophys. J. 15:257a (1975).

13. Lieberman, M., Shigeto, N., Kootsey, J.M., Johnson, E.A. Ionic currents in cardiac muscle. Fed. Proc. 34:391 (1975).

14. Kootsey, J.M., Johnson, E.A. The T-wave: Membrane origins. Vth Int. Biophys. Congr. Abstracts, p 27 (1975).

15. Kootsey, J.M. The three-electrode voltage-clamp method for nonlinear cables: A dynamic test by computer simulation. Proc. Int. Union Physiol. Sci. 8:401 (1977).

16. Rowland, S.C., Kootsey, J.M. Comparing impulse measurements. AAPT Apparatus Competition (Third prize; open category) (1979).

17. Kootsey, J.M., Chapman, J.B., Johnson, E.A. A kinetic model for determining the consequences of electrogenic active transport in cardiac muscle. Biophys. J. 25:199a (1979).

18. Chapman, J.B., Kootsey, J.M., Johnson, E.A. A kinetic model for determining the consequences of electrogenic active transport in cardiac muscle. I. The stationary state. Proc. Austral. Physiol. & Pharm. Soc. (1979).

19. Johnson, E.A., Kootsey, J.M., Chapman, J.B. A kinetic model for determining the consequences of electrogenic active transport in cardiac muscle. II. Effect of rate of stimulation. Proc. Austral. Physiol. & Pharm. Soc. (1979).

20. Kootsey, J.M. Thermodynamic constraints in modeling ion transport: An example from cardiac electrophysiology. Symposium on Mathematical Modeling of Metabolic and Endocrine Systems, University of Surrey, Guildford, Surrey, UK. p 143 (1980).

21. Kootsey, J.M., Johnson, E.A., Chapman, J.B. Electrochemical inhomogeneity in ungulate Purkinje fibers: Model of electrogenic transport and electrodiffusion in clefts. Proc. XXVIII Int. Cong. Physiol. Sci., Budapest. 8:83-92 (1980).

22. Kootsey, J.M., Johnson, E.A. Na-Ca Exchange: A thermodynamically-constrained kinetic model and role in E-C coupling. Biophys. J. 33:5a (1981).

23. Kootsey, J.M., Chapman, J.B., Johnson, E.A. Physiological modeling of an electrogenic vectorial enzyme. Fed. Proc. 41:1614 (1982).

24. Spach, M.S., Sloan, J.D., Kootsey, J.M., Saul, J.P. Analysis of propagation of depolarization based on quantitative description of activation kinetics of fast sodium current in cardiac muscle. Circ. 66:II-233 (1982).

25. Chapman, J.B., Johnson, E.A., Kootsey, J.M. On the use of metabolic poisons to determine the current-voltage relation of an electrogenic active transport mechanism. Proc. Australian Physiol. Soc. (1982).

26. Spach, M.S., Sloan, J.D., Kootsey, J.M., Colatsky, T.J. Quantitative description of propagated cardiac depolarization as a function of rest potential with experimental verification. Circ. 68:III-23 (1983).

27. Spach, M.S., Sloan, J.D., Kootsey, J.M. Reconstruction of propagating depolarization in cardiac muscle based on voltage clamp data. Biophys. J. 45:278a (1984).

28. Kootsey, J.M. Computer models in toxicology: Analysis or synthesis? Seminar on Modelling and Simulation for Safety and Risk Assessment, London (1983).

29. Johnson, E.A., Kootsey, J.M., Chapman , J.B. Electrical and chemical properties of an enzyme model of Na/Ca exchange. Fed. Proc. 43:495 (1984).

30. Kootsey, J.M. The National Biomedical Simulation Resource: Microcomputers to megacomputers. 2nd Annual Conference on Computers in Science, Washington, D.C. (1984).

31. Kootsey, J.M., Johnson, E.A. Electrical and chemical properties of an enzyme model of Na+,Ca++ exchange. Proc. 8th Intl. Biophysics Congress, Bristol, U.K. p 296 (1984).

32. Kootsey, J.M., Johnson, E.A. Intracellular Ca++ regulation: Synthesis on the NBSR AD-10. Proc. 38th Annual Conf. Eng. Med. Biol. 27:59 (1985).

33. Kootsey, J.M. SCoPFIT -- Fitting a simulation model to data on a microcomputer. Southeastern Simulation Council, Orlando, FL (1985).

34. King, R., Budd, R., Bassingthwaighte, J.B., Kootsey, J.M., and Leonard, D. SimSys - A simulation system for biological investigators. Fed. Proc. 45:169 (1986).

35. Johnson, E.A., and Kootsey, J.M. Intracellular calcium dynamics: Reconstruction by computer simulation. Proc. XXX Cong. Int. Union Physiol. Sci. 16:129 (1986).

36. Spach, M.S., Dolber, P.C., Kootsey, J.M., and Johnson, E.A. Accounting for anisotropic behavior of propagation by directional differences of membrane capacity in human cardiac muscle. Circulation 74:II-419 (1986).

37. Menzel, D.B., Kootsey, J.M., and Wolpert, R.L. Simulation resources. Pharmacokinetics in Risk Assessment Workshop, National Academy of Sciences and National Research Council, Washington, DC, 1986.

38. Vaughan, P.C., Kootsey, J.M., and Feezor, M.D. Macroscopic kinetics of chloride conductance in frog muscle at pH 5. Biophys. J. 51:200a (1987).

39. Kootsey, J.M., and Johnson, E.A. A mechanistic description of Na,Ca exchange: Updates in light of recent data. Proc. Austr. Physiol. Pharm. Soc. 18:106P (1987).

40. Johnson, E.A., Kootsey, J.M., and Wood, S.A. A working mechanism for Na,Ca exchange: Updated voltage dependence and Ca,Ca exchange. First International Meeting on Sodium-Calcium Exchange, Stowe School, Buckinghamshire, U.K., July 12-16, 1987.

41. Kootsey, J.M. Calculating unidirectional fluxes in simulated transport reactions. Southeastern Simulation Conference, Huntsville, Alabama, Oct. 19-21, 1987.

42. Kootsey, J.M. A second-generation software system for biomedical simulation. 12th IMACS World Congress on Scientific Computation, Paris, July 18-22, 1988.

43. Kootsey, J.M. Anisotropic propagation of electrical activity in cardiac muscle. 12th IMACS World Congress on Scientific Computation, Paris, July 18-22, 1988.

44. Kootsey, J.M. Enzyme-mediated ion transport. Phys. Med. Biol. 33:S1:157, 1988.

45. Kootsey, J.M., Wu, J. Anisotropic 2-D circuit model for electrical propagation in cardiac muscle. IEEE Eng. Med. Biol. Society, New Orleans, Louisiana, November 3-7, 1988.

46. Lemieux, D.R., Johnson, E.A., Kootsey, J.M. A symmetric mechanism for Na-Ca exchange. Biophys. J. 55:167a, 1989.

47. Rowland, S.C., Kootsey, J.M. Classical mechanics experiments in the advanced physics laboratory combined with computer simulation: the falling chain problem. AAPT Announcer 19:4:53, 1989.

48. Kootsey, J.M., Pusateri, T.J. SimSys: A distributed model and simulation environment. Southeastern Simulation Conference, Huntsville, Alabama, October 22-23, 1990.

49. Johnson, E.A., Lemieux, D.R., and Kootsey, J.M. Sodium-calcium exchange: Derivation of a state diagram and rate constants from experimental data. Second International Conference on Sodium/Calcium Exchange, Baltimore, Maryland, April 8-10, 1991.

50. Kootsey, J.M. Complex simulation models in the SCoP language. Western Simulation Multiconference, La Jolla, California, January 18-20, 1993.

51. Kootsey, J.M. SCoP: Applications of simulation software to ion transport and regulation. Third International Conference on Sodium-Calcium Exchange, Wood's Hole, Massachusetts, April 23-26, 1995.

52. Kootsey, J.M. Software for the third branch of science: Experimental Theory. Second International Conference on Knowledge Acquisition, Representation, and Processing (KARP-95), Auburn University, Auburn, Alabama, September 27-30, 1995.

53. Kootsey, J.M. Computational issues in modeling a hierarchical biological system. Summer Computer Simulation Conference (SCSC2000), Vancouver, British Columbia, July 16-20, 2000.

54. Kootsey, J.M., McAuley, G., and Liu, H. Presenting systems concepts in Pharmacology and Physiology with simulation applets in Java. Western Group on Educational Affairs (AAMC), Univ. California Los Angeles, April 20-22, 2001.

55. Kootsey, J.M., Liu, H.H., McAuley, G. Learning the behavior of complex systems with computer simulation. TechEd 2002 Best Practices Showcase, Long Beach, CA, Feb. 26, 2002.

56. Kootsey, J.M., McAuley, G., Liu, H.H. Building interactive Web page simulations with a library of Java applets. Western Group on Educational Affairs (AAMC), Asilomar, California, April 27 - May 1, 2002.

57. McAuley, G., Liu, H., Kootsey, J.M. Learning Physiology with Interactive Web Based Simulations. Fifth Annual Research Symposium, Loma Linda University, Loma Linda, California, Sept. 11-12, 2002.

58. Kootsey, J.M., McAuley, G. NLX: Building Web Pages with Interactive Calculations in Minutes. 25th International Conference of the IEEE Engineering in Medicine and Biology Society, Cancun, Mexico, Sept. 17-21, 2003.

59. Kootsey, J.M., McAuley, G. NumberLinX: A Software Technology for Rapid Construction of Interactive Web Pages Based on Mathematical Calculations. Project T2 - A Technology Transfer Conference (a LARTA event), Los Angeles, California, November 13, 2003.

60. Kootsey, J.M., McAuley, G., Siriphongs, D. NLX: Rapid Construction of Interactive Simulations for the Web. 2004 Western Simulation Multiconference (Society for Computer Simulation), San Diego, California, January 18-22, 2004.

61. Kootsey, J.M., Siriphongs, D., McAuley, G. Building Interactive Simulations in a Web Page Design Program. 26th Annual Conference of the IEEE Engineering in Medicine and Biology Society, San Francisco, California, USA, Sept. 1-5, 2004.

62. Kootsey, J.M., McAuley, G. NLX: Rapid Construction of Interactive Simulations in Web Pages for Teaching and Research. Experimental Biology 2005, San Diego, California, USA, April 2-6, 2005.

63. Kootsey, J.M., McAuley, G. NumberLinX: A System for Rapid Construction of Interactive Calculations in Web Pages. 1st Intl. Conf. on Development of Biomedical Engineering in Vietnam, Ho Chi Minh City, July 27-29, 2005.

64. Kootsey, J.M., McAuley, G., Bernal, J. Building Interactive Simulations in Web Pages Without Programming, 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference, Shanghai, China, September 1-4, 2005.

65. Kootsey, J.M. Rapid Construction of Interactive Simulations in Web Pages Using NumberLinX (a workshop). 6th International Meeting on Medical Simulation (Society for Medical Simulation), San Diego, California, USA, January 14-17, 2006.

66. Kootsey, J.M. Rapid Constrtuction of Interactive Simulations in Web Pages Using NumberLinX. Slice of Life 2006, Lausanne, Switzerland, July 4-8, 2006.

67. Kootsey, J.M. NumberLinX: Rapid Development of Interactive Numerical Web Content. VIPSI-2006 Venice, Oct. 12-14, 2006.

68. Kootsey, J.M. Interactive Simulation in Web Pages: A System for Rapid Development. Asia Modeling Symposium AMS2007, Phuket, Thailand, March 27-30, 2007.

69. Kootsey, J.M., McAuley, G. Rapid Construction of Simulation-Driven Animations In Web Pages Using NLX and Flash. 17th Annual International Conference on Health Science Simulation, Ottawa, Canada, April 14-16, 2008.

70. Kootsey, J.M., McAuley, G. NLX Plus Flash Equals Quick Simulation-Driven Animations. Second Annual Asia Modelling Symposium AMS2008, Kuala Lumpur, Malaysia, May 13-15, 2008.

71. Kootsey, J.M. Evaluating the Quality of Mathematical Models. Information Systems, Modeling and Simulation (ISMS 2011). (Phnom Penh, Cambodia, January 27, 2011).

72. Kootsey, J.M. How I Became a Computational Scientist. 16th International Conference on Computer Modeling and Simulation UKSIM 2014, Cambridge, UK, March 26-28, 2014.

73. Karanikas, V., Teichgraber, V., Phipps, A., Charoin, J.E., Kootsey, J.M., Wagg, J. Optimizing Delivery of Cancer Vaccines: Short Peptides. Pharma Research and Early Development Science Day (Roche), Basel, Switzerland, June 9, 2015.

 


REPORTS, LAY PRESS, BLOGS, AND OTHER PUBLICATIONS:

1. Book Review: The Encounter Between Christianity and Science (Richard Bube). Loma Linda University SCOPE Jan. 2, p8 (1969).

2. Kootsey, J.M. Reaction to "Who to Believe", A Protest. Insight, Jan. 5, 1971, pp 12-15.

3. Kootsey, J.M. Man: Creature and explorer. Origins 2:19-25 (1975).

4. Kootsey, J.M. Can the Christian afford scientific research? Origins 3:97-101 (1976).

5. Kootsey, J.M. The scientist as a man of faith. Ministry, Nov. 1978, pp 24-26.

6. Kootsey, J. M., and Johnson, E. A. Computers in basic science medical education. Department of Physiology Report, Duke Univ. Med. Center (1982).

7. Collegiate Quarterly, Second Quarter, 1992, Lesson 11: Edited the six articles making up the lesson and wrote the EVIDENCE article "Cosmic King".

8. Kootsey, J.M., A doctor in the house. Pages 186-187 in College Faith, Ronald A. Knott, ed. (Pacific Press Publishing Association, Boise, Idaho, 1995).

9. Kootsey, J.M., Understanding how nature works: Last piece of the puzzle? Dialogue 8:2, pp 8-10 (1996).

10. Kootsey, J.M., The distributed university: Having our cake and eating it too. Spectrum 28:2, pp 54-57 (2000).

11. Kootsey, J.M., What makes science valuable? Part 1: Observations, experiments, and theories. http://spectrummagazine.org/blog/2012/07/09/bringing-real-world-genesis-what-makes-science-valuable-part-1-observations-experime (2012).

12. Kootsey, J.M., What makes science valuable? Part 2: Developing scientific ideas. http://spectrummagazine.org/blog/2012/07/30/bringing-real-world-genesis-what-makes-science-valuable-part-2-developing-scientific (2012).

13. Kootsey, J.M. What makes science valuable? Part 3: Caprice and law. http://spectrummagazine.org/blog/2012/08/07/bringing-real-world-genesis-what-makes-science-valuable-part-3-caprice-and-law (2012).

14. Kootsey, J.M. Ultra-Darwinists and conservative Christians agree! http://www.atoday.org/article/1011/blogs/taylor-ervin/2012/ultra-darwinists-and-conservative-christians-agree (2012).

15. Kootsey, M. and Taylor, E. Intelligent Design: Whatever it is, it's not science. Adventist Today, 21:1 pp 24-26 (2013).

16. Kootsey, M. Why does the public reject science? http://www.atoday.org/article/1700/blogs/visiting-bloggers/why-does-the-public-reject-science (2013).

17. Kootsey, J.M. Sources of Variation in Biology. Part 1: Randomness and Chaos. http://spectrummagazine.org/blog/2013/08/12/bringing-real-world-genesis-randomness-and-chaos (2013).

18. Kootsey, J.M. Sources of Variation in Biology. Part 2: Emergence. http://spectrummagazine.org/blog/2013/08/27/bringing-real-world-genesis-emergence (2013).

19. Kootsey, J.M. Sources of Variation in Biology. Part 3: Emergence and Origins of Life. http://spectrummagazine.org/blog/2013/09/12/sources-variation-biology-part-3-emergence-and-origins-life (2013).

20. Kootsey, J.M. To Create. Spectrum 43:4, pp 50-57 (2015).

 

 


 

GRANTS AND CONTRACTS:

( Names listed are the Principal Investigators. J. Mailen Kootsey is a Co-Investigator for those grants where he is not the Principal Investigator. Dollar amounts are direct costs only.)

1. Study of Cardiac Repolarization Process. J. Mailen Kootsey. National Institutes of Health Research Fellowship (1 F03 HE43004), 9/69 - 8/71. $20,675.

2. NIH Research Fellowship (5 F03 HE43004-02), 7/70-6/71. $10,750.

3. Piezoelectric-driven Microelectrodes for Recording from Isolated Heart Cells. Melvyn Lieberman. Research Awards Committee Duke University Medical Center, 1/70 - 12/70. $925.

4. Excitation Spread in Linear Arrays of Heart Cells. J. Mailen Kootsey. North Carolina Heart Association (1969-70-A-15), 2/70 - 1/72. $2,500.

5. Computer Study of Slow Electrical Propagation in Heart Cells. J. Mailen Kootsey. North Carolina Heart Association (1970-71-A-40), 2/71 - 1/72. $2,370.

6. Graphics Terminal Interface for Simulation. J. Mailen Kootsey. Research Awards Committee Duke University Medical Center, 11/74 - 10/75. $1,300.

7. The T-Wave and Its Implications for Ionic Mechanisms of Repolarization. J. Mailen Kootsey. North Carolina Heart Association (1975-76-A-7), 4/75 - 3/76. $2,500.

8. Functions and Mechanisms of Cell Membrane Ion Transport. Edward A. Johnson. (*J.M. Kootsey added as a co-investigator after submission of application). National Institutes of Health, 4/78 - 3/83. $3,106,216.

9. Biophysical Studies in Pediatric Cardiology. Madison S. Spach. National Institutes of Health (HL11307), 5/82 - 4/92. $3,128,511.

10. National Biomedical Simulation Resource. J. Mailen Kootsey. National Institutes of Health (RR01693), 9/83 - 8/90. $4,160,875.

11. IAIMS Pilot Implementation. William W. Stead. National Institutes of Health (2G08LMO4613), 12/86 - 11/89. $1,498,751.

12. Expert System for Biomedical Computer Simulation. J. Mailen Kootsey. American Telephone & Telegraph, 1/88 - 12/90. $184,500.

13. Adding SCoP to PROPHET II (SBIR Phase I Contract). J. Mailen Kootsey. National Institutes of Health (N43-RR-2-2104), 6/92 - 12/92. $45,547.00.

14. Adding SCoP Simulation to PROPHET II (SBIR Phase II Contract). J. Mailen Kootsey. National Institutes of Health (N44-RR-3-2137), 10/93 - 4/97. $493,391.

15. Multi-Domain Model Entry for Computer Simulation. J. Mailen Kootsey. National Medical Testbed (0315-8860-01), 3/2000-2/2001. $81,043.

16. Building Simulation Applets for Teaching the Behavior of Biomedical Systems. J. Mailen Kootsey, National Medical Testbed, 2001-2002, $13,540.

17. A Interactive Development Environment for Web Pages with Multi-Applet Simulations. J. Mailen Kootsey, National Medical Testbed, 3/2003 - 2/2004, $5,000.

 


 

PATENTS:

1. Improvements in respiration testing system. US Patent No. 3,659,590 with W.C. Jones (1972).

2. System for building interactive calculations in Web pages. US Patent No. 7,568,181 with G. McAuley and H. Liu (2009).

Last modified: May 24, 2017 by Mailen Kootsey